Profhilo or Dermal Filler? What's the difference?

Profhilo and dermal fillers are both popular treatments for rejuvenating the skin and reducing the signs of ageing. However, they have some key differences in terms of their composition, application, and results.Whether you’re a seasoned pro when it comes to injectables, or you’re looking to dip your toe in for the first time, there is a treatment suited for all faces and skin goals. And the key to deciphering which is right for you is to first understand what each of the treatments does, and how they do it. 

When it comes to reversing the signs of ageing, more and more people are turning to injectable treatments, out of which 2 that are most popular are  Dermal Filler and Profhilo. And while there are some similarities between them they are actually two different anti-ageing treatments. So let’s break them down… 


Profhilo is a unique injectable treatment that contains a highest concentration of hyaluronic acid (HA) 64mg/2mls, made up of 32mg high molecular weight and 32mg low molecular weight HA, a naturally occurring substance in the body. It is a HA bio-stimulator used to enhance various areas of the body, especially face and neck. Profhilo is known for its regenerative anti ageing treatment which reverses the ageing process through bio remodeling of the skin without volumising the areas of treatment.

How does Profhilo work?

Profhilo is injected into specific points on the face using a technique called Bio Aesthetic Points (BAP). It spreads beneath the skin, working on the different layers of skin and superficial fat compartments, stimulating collagen and elastin production and restoring aged tissues, resulting in improved skin quality, texture, tone and hydration.

Containing one of the highest concentrations of Hyaluronic Acid on the market, the revolutionary ‘beneath the skin' moisturising treatment is made with the patented NAHYCO technology, which makes it possible to deliver these high levels of hyaluronic acid safely and effectively. 

HA Dermal Fillers 

Dermal fillers are a type of cosmetic injectable that contains hyaluronic acid (HA) as the main ingredient. Hyaluronic acid is a naturally occurring substance in the body that helps to hydrate and plump the skin. HA dermal fillers are used to restore volume, smooth out wrinkles and fine lines, and enhance facial contours.These fillers come in various formulations and consistencies, allowing for customised treatment based on the specific needs and goals of the individual.

How does Dermal Filler work?

These fillers are injected into the different areas of the face to add volume, hydration and plumpness, resulting in a more youthful and rejuvenated appearance. Commonly used in areas such as lips, cheeks, nasolabial folds, marionettes and jawlines.

Your skin's surface will appear smoother, and fine lines and folds will be less visible. And you want to know the best part? The results are instant and you will notice the hydration, especially in the lips.

The effects of HA dermal fillers are temporary and typically last for several months to a year, depending on the specific product used and individual factors.

What’s the difference between Profhilo and fillers?

The common factor between the 2 products is Hyaluronic acid however the process of production of each product gives it the unique ability to behave differently when injected into the skin. 

The rheology of HA used in dermal filler injectables is thicker and more viscous than the runnier consistency of Profhilo injections. The HA that is found in dermal fillers contains lidocaine -a local anaesthetic agent, unlike Profhilo which is highly concentrated and purified HA without any lidocaine. So whilst hyaluronic acid makes an appearance in both treatments, the rheology of HA used is actually substantially different.

Once dermal fillers are injected into an area on the face, the product stays in the area and integrates into the skin's natural fibres given its crossed linked nature which is why it works so well for targeted areas such as the lips, cheeks. On the other hand, Profhilo injections will disperse the HA underneath the skin, spreading its moisturising magic across the whole face. 

Dermal fillers are a game changer for those who want to enhance certain parts of the face such as plumping the lips or shaping the jawline by replacing lost volume. Profhilo doesn’t play a role in volumising or restructuring the face, however. Think of Profhilo as a really really hydrating facial, but rather than layering the products on top of the skin, you are injecting it into the skin. This will give you that lit-from-within glow and be able to give the entire face a glowy complexion, rather than just certain areas. It works as an under skin nourishment for underlying tissues. 

How long does each treatment last?

Dermal Filler 

Results vary from person to person, but clients can usually expect their dermal fillers to last between 6 to 24 months. This depends largely on the personal individual metabolism and skin care regimen, as well as the area treated. We recommend getting treatments once or twice a year (depending on the area) to achieve and maintain your desired look. 


Again results will vary from person to person, however, typically they last 6-9 months depending on your age, skin type and metabolism. We recommend that you have maintenance treatments at least once a year to maintain the best results. 

What is the difference in cost?

Dermal Fillers

Again, costs vary depending on where you want it done, and how much you want done. This will all be discussed during your free consultation so there won’t be any surprises on the day! If you want to spread out the payments, you can look at signing onto one of our Amerase cosmetic injectable plans. This way, you spread the cost out over weekly, fortnightly or monthly payments! You also get a tonne of added benefits including exclusive discounts, freebies and 10% off Skinsmiths skincare! 


The first time you have Profhilo, you will require two appointments with the registered nurse roughly four weeks apart from each other. For new customers, these initial treatments will cost $1700, or if you sign up for an Amerase Membership, around $159 per week. 

For our existing customer, the cost for the initial two treatments is $1600 which is roughly $150 per week on the Amerase Membership. Then your ongoing maintenance appointments which you can get every 6-9 months are $850 per treatment, which works out to be $32 per week. As injectables go, Profhilo is at the higher end of the cost spectrum, however, the results have been well-documented to be life-changing, so we would argue that it is absolutely worth it to look and feel your best. 

So which one should you choose, dermal filler or Profhilo?

So while both treatments are beneficial to most people, when you’re deciding which one to get, it’s important to think long and hard about what you want to get out of it. If you’re wanting to plump your pout or cheeks, then dermal fillers are the way to go as results are instantaneous. But if you want to give your face an all-over glow-up and give it an unmatched hydration boost then you might want to look into Profhilo which is a more gradual process to skin  enhancement.

If you want to speak to an expert about how best to reach your specific skincare goals, then book a free consultation are your local Caci Clinic and they’ll be able to offer you advice on which treatment is right for you. While they both have significant differences, they both offer exceptional results!